Herbal Extract
Rephyl® (Piper nigrum) Extract
Also known as: black pepper extract, Piper nigrum fruit extract, beta-caryophyllene rich black pepper, Rephyll
Rephyl® is a standardized black pepper (Piper nigrum) fruit extract concentrated for beta-caryophyllene (6%), a sesquiterpene with potential anti-inflammatory and neuroprotective properties. Limited human clinical evidence exists; most research is in vitro or animal models.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Anti-inflammatory support
- Neuroprotection
- Cognitive support
How it works
- CB2 cannabinoid receptor agonism (beta-caryophyllene)
- Inhibition of NF-κB inflammatory pathway
- TRPV1 and other nociceptor modulation
Dosage
- Typical range
- 500-1500 mg daily (as standardized extract; approximately 30-90 mg beta-caryophyllene)
- Timing
- With meals for optimal absorption
- With food
- Recommended; fat-soluble compound absorption enhanced with food
- Duration
- No standard duration established; longer-term safety data lacking
- Special populations
- Pregnant/nursing women should consult healthcare provider; use in children not established
Forms
- Capsule· 70/100
- Powder· 70/100
Safety
Common side effects
- Generally well-tolerated at typical doses
- Rare: mild gastrointestinal upset
Contraindications
- Hypersensitivity to black pepper or related Piperaceae species
- Caution with aspirin sensitivity or bleeding disorders (preliminary evidence for mild anticoagulant effect)
Products containing Rephyl® (Piper nigrum) Extract
Top-scoring supplements in our catalog that list Rephyl® (Piper nigrum) Extract on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Beta-caryophyllene shows promising in vitro and animal data for anti-inflammatory and neuroprotective effects, but human clinical trials in humans are limited and small. Rephyl® as a proprietary standardized extract lacks dedicated RCT evidence in humans.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.