Amino Acid
Pyroglutamic Acid
Also known as: L-pyroglutamic acid, 5-oxoproline, PCA, L-pyroglutamate
An amino acid intermediate in glutathione metabolism and protein synthesis. Used as a nootropic due to proposed cognitive and memory-supporting properties.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Cognitive support
- Memory enhancement
- Glutathione synthesis support
How it works
- Glutathione precursor
- Potential neurotransmitter modulation
- Antioxidant pathway support
Dosage
- Typical range
- 500-1500 mg daily (divided doses)
- Timing
- Morning and/or with meals
- With food
- May improve absorption with food
- Duration
- Typically used long-term; effects may develop gradually over weeks
- Special populations
- Generally regarded as safe; limited pediatric data
Forms
- Capsule· 70/100
- Powder· 70/100
Safety
Common side effects
- Rare; mild GI upset possible at high doses
Products containing Pyroglutamic Acid
Top-scoring supplements in our catalog that list Pyroglutamic Acid on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
See all products →
Evidence notes
Older clinical literature (1970s-1980s) suggests cognitive benefits, but modern RCT evidence is sparse. Primarily used in European supplements; limited contemporary human data.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Amino Acid
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does Pyroglutamic Acid fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.