Amino Acid
Pyroglutamic Acid
Also known as: L-pyroglutamic acid, 5-oxoproline, PCA, L-pyroglutamate
An amino acid intermediate in glutathione metabolism and protein synthesis. Used as a nootropic due to proposed cognitive and memory-supporting properties.
Primary uses
- Cognitive support
- Memory enhancement
- Glutathione synthesis support
How it works
- Glutathione precursor
- Potential neurotransmitter modulation
- Antioxidant pathway support
Dosage
- Typical range
- 500-1500 mg daily (divided doses)
- Timing
- Morning and/or with meals
- With food
- May improve absorption with food
- Duration
- Typically used long-term; effects may develop gradually over weeks
- Special populations
- Generally regarded as safe; limited pediatric data
Forms
- Capsule· 70/100
- Powder· 70/100
Safety
Common side effects
- Rare; mild GI upset possible at high doses
Products containing Pyroglutamic Acid
Top-scoring supplements in our catalog that list Pyroglutamic Acid on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Older clinical literature (1970s-1980s) suggests cognitive benefits, but modern RCT evidence is sparse. Primarily used in European supplements; limited contemporary human data.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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