Amino Acid

Choline (as DL-Choline Bitartrate)

Also known as: choline bitartrate, DL-choline bitartrate, choline salt

Evidence

Choline (as DL-choline bitartrate) is an essential nutrient required for neurotransmitter synthesis, cell membrane integrity, and lipid metabolism. Bitartrate is an inexpensive salt form with moderate bioavailability.

Find the best Choline (as DL-Choline Bitartrate) supplements — free

See Choline (as DL-Choline Bitartrate) products scored on dose & form, then track your intake in the app.

Open app →

Daily target & upper limit

550 mg / day · UL 3500 mg

Choline (as DL-Choline Bitartrate) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

Choline (as DL-Choline Bitartrate) dosage reference →

Primary uses

cognitive function
liver health
cell membrane structure
neurotransmitter synthesis

How it works

precursor to acetylcholine (neurotransmitter)
component of phosphatidylcholine
methyl donor for homocysteine metabolism

Dosage

Typical range: 250–600 mg daily
Timing: can be taken anytime; typically with meals for GI tolerance
With food: Taking with food may improve tolerance and absorption
Duration: Safe for long-term use; adequate intake 550 mg (men), 425 mg (women)
Special populations: Pregnant/lactating women: 930 mg daily; DL form has lower activity than L-form

Forms

DL-choline bitartrate· 70/100

Safety

Common side effects

fish-like body odor (rare, dose-dependent)
nausea
abdominal discomfort

Contraindications

trimethylaminuria (TMAU) or genetic predisposition

Products containing Choline (as DL-Choline Bitartrate)

Top-scoring supplements in our catalog that list Choline (as DL-Choline Bitartrate) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne

MediClear-SGS™ - Vanilla

MediClear-SGS™ - Chocolate

See all products →

Evidence notes

Choline has good evidence for liver and cognitive health; bitartrate form has moderate bioavailability; more bioavailable forms include CDP-choline and choline alphoscerate.

Grade B: Some human trials support key claims; further confirmation needed.

Related in Amino Acid

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.