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Amino Acid

Choline (as DL-Choline Bitartrate)

Also known as: choline bitartrate, DL-choline bitartrate, choline salt

B
Evidence

Choline (as DL-choline bitartrate) is an essential nutrient required for neurotransmitter synthesis, cell membrane integrity, and lipid metabolism. Bitartrate is an inexpensive salt form with moderate bioavailability.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Daily target & upper limit

550 mg / day · UL 3500 mg

Choline (as DL-Choline Bitartrate) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

Choline (as DL-Choline Bitartrate) dosage reference →

Primary uses

  • cognitive function
  • liver health
  • cell membrane structure
  • neurotransmitter synthesis

How it works

  • precursor to acetylcholine (neurotransmitter)
  • component of phosphatidylcholine
  • methyl donor for homocysteine metabolism

Dosage

Typical range
250–600 mg daily
Timing
can be taken anytime; typically with meals for GI tolerance
With food
Taking with food may improve tolerance and absorption
Duration
Safe for long-term use; adequate intake 550 mg (men), 425 mg (women)
Special populations
Pregnant/lactating women: 930 mg daily; DL form has lower activity than L-form

Forms

  • DL-choline bitartrate· 70/100

Safety

Common side effects

  • fish-like body odor (rare, dose-dependent)
  • nausea
  • abdominal discomfort

Contraindications

  • trimethylaminuria (TMAU) or genetic predisposition

Products containing Choline (as DL-Choline Bitartrate)

Top-scoring supplements in our catalog that list Choline (as DL-Choline Bitartrate) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Transparent Labs
BULK Pre-Workout
90
Thorne
Advanced Nutrients
88
Thorne
Basic Prenatal
88
Thorne
Men's Multi 50+
88
See all products →

Evidence notes

Choline has good evidence for liver and cognitive health; bitartrate form has moderate bioavailability; more bioavailable forms include CDP-choline and choline alphoscerate.

Grade B: Some human trials support key claims; further confirmation needed.

Related in Amino Acid

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.