Amino Acid
Sarcosine
Also known as: N-methylglycine, 2-methylglycine, methylaminoacetic acid
Sarcosine is an endogenous amino acid and glycine metabolite that modulates NMDA receptor function and may have potential benefits for cognitive function and mood. Limited human clinical evidence supports its use as a nootropic agent.
Primary uses
- Cognitive function
- Memory support
- Mood support
- NMDA receptor modulation
How it works
- Antagonizes glycine transporter-1 (GlyT1), increasing glycine availability at NMDA receptors
- Modulates glutamatergic neurotransmission
- May enhance synaptic plasticity
Dosage
- Typical range
- 1-2 grams daily
- Timing
- Divided doses, typically once or twice daily
- With food
- No specific requirement; can be taken with or without food
- Duration
- Long-term safety data limited; typical studies use 4-12 week durations
- Special populations
- Pregnant/nursing women should avoid; limited safety data in pediatric populations
Forms
- Tablets· 70/100
- Powder· 70/100
- Capsules· 70/100
Safety
Common side effects
- Generally well-tolerated at typical doses
- Headache (rare)
- Nausea (rare)
Contraindications
- Schizophrenia or psychotic disorders (potential risk of exacerbation)
- Pregnancy and lactation (insufficient safety data)
- History of seizures (limited safety information)
Evidence notes
Limited human clinical trials, primarily small studies and preliminary research. Most evidence derives from mechanistic and animal studies. Human efficacy data for cognitive benefits remain preliminary.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Amino Acid
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerMedical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.