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Nootropic

Modafinil (Informational)

Also known as: Provigil, Alertec

A
Evidence

Prescription wakefulness agent used off-label for cognitive enhancement. Requires prescription in most countries.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Wakefulness
  • Focus
  • Cognitive enhancement

How it works

  • Histamine and orexin modulation
  • Dopamine reuptake inhibition
  • Promotes wakefulness without typical stimulant effects

Dosage

Typical range
100-200 mg (by prescription)
Timing
Morning
With food
Optional
Duration
As prescribed
Special populations
Narcolepsy, shift work (FDA approved)

Forms

  • Tablet

Safety

Common side effects

  • Headache
  • Nausea
  • Insomnia
  • Anxiety

Contraindications

  • Heart conditions
  • History of psychosis

Evidence notes

Prescription medication - well-studied

Grade A: Multiple well-designed human trials support the main claims.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.