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Liver Detox Support Stack

Also known as: Liver support stack, Hepatoprotective protocol

A
Evidence

Comprehensive liver support: Milk Thistle, NAC, and TUDCA for protection, detox, and bile flow.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Liver protection
  • Phase II detox
  • Bile flow
  • Hepatoprotection

How it works

  • Hepatocyte protection
  • Glutathione support
  • Bile acid support
  • Phase II enhancement

Dosage

Typical range
Milk Thistle 300-600mg (80% silymarin) + NAC 600-1200mg + TUDCA 250-500mg
Timing
With meals, divided doses
With food
Yes
Duration
Ongoing or cycling based on need
Special populations
Those with liver concerns, alcohol users, medication users, steroid users

Forms

  • Separate supplements

Safety

Common side effects

  • GI upset
  • NAC sulfur smell

Contraindications

  • Complete bile duct obstruction (TUDCA)

Evidence notes

Well-supported liver combination

Grade A: Multiple well-designed human trials support the main claims.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.