Nootropic
Hordenine
Also known as: N,N-dimethyltyramine
MAO-B inhibitor that extends effects of PEA and provides mild stimulation.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- PEA extension
- Mild stimulation
- Focus
How it works
- MAO-B inhibition
- Extends PEA half-life
- Mild adrenergic effects
Dosage
- Typical range
- 25-50 mg
- Timing
- With PEA
- With food
- Optional
- Duration
- Support compound
- Special populations
- PEA users
Forms
- Capsules
- Powder
Safety
Common side effects
- Stimulation
- Rapid heart rate
Contraindications
- MAOIs
- Heart conditions
Evidence notes
MAO-B inhibitor for PEA stacks
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Nootropic
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.