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Herbal Extract

Holy Basil (Tulsi) Supercritical Extract

Also known as: Ocimum sanctum supercritical extract, Tulsi supercritical extract, Holy basil aerial parts extract, Supercritical holy basil

C
Evidence

Supercritical CO2 extract of holy basil aerial parts standardized to eugenol and caryophyllene, traditional Ayurvedic herb studied for stress-adaptive and antioxidant properties. Limited human clinical evidence supports traditional use, though constituent compounds show in vitro bioactivity.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Stress and anxiety support
  • Cognitive function
  • Antioxidant support
  • Adaptogenic effects

How it works

  • Eugenol and caryophyllene may modulate stress hormone pathways
  • Antioxidant activity via polyphenol content
  • Potential GABA-modulating effects (preliminary)
  • Anti-inflammatory mechanisms

Dosage

Typical range
300-1200 mg daily (varies by product concentration)
Timing
Divided doses with meals optimal
With food
May be taken with or without food; with food may reduce any stomach sensitivity
Duration
Traditionally used long-term; 4-8 weeks typically assessed for adaptogenic effects
Special populations
Avoid if pregnant/nursing; caution with immunosuppressants or hormone-sensitive conditions

Forms

  • Supercritical extract· 70/100
  • Liquid extract· 70/100

Safety

Common side effects

  • Mild gastrointestinal upset
  • Rare allergic reactions in sensitive individuals

Contraindications

  • Pregnancy and lactation
  • Immunosuppressive therapy (may enhance immune activity)
  • Hormone-sensitive cancers (theoretical concern from traditional use)

Evidence notes

Holy basil has moderate traditional use evidence and some human studies on stress/anxiety outcomes, but limited rigorous RCT data specifically on supercritical extracts with this standardization. Eugenol and caryophyllene show in vitro activity but human efficacy data is preliminary.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.