Stack

Cortisol Management Stack

Also known as: Cortisol stack, Stress reduction stack

Evidence

Stress and cortisol support: Ashwagandha, Phosphatidylserine, Holy Basil, Magnesium.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Cortisol reduction
Stress management
HPA axis balance

How it works

Multi-mechanism cortisol support
Adaptogenic balance
Nervous system support
HPA axis modulation

Dosage

Typical range: Ashwagandha 300-600mg (PM) + Phosphatidylserine 100-300mg (PM/pre-workout) + Holy Basil 300-600mg + Magnesium glycinate 200-400mg (PM)
Timing: Ashwagandha and PS evening, Holy Basil flexible
With food: Mixed
Duration: Ongoing stress support
Special populations: High cortisol, chronic stress, poor stress recovery

Forms

Separate supplements

Safety

Common side effects

See individual components

Contraindications

See individual components

Evidence notes

Evidence-based cortisol and stress support

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.