Performance

Arachidonic Acid (ARA)

Also known as: ARA, Arachidonic acid, X-Factor

Evidence

Omega-6 fatty acid that amplifies exercise-induced muscle signaling. Increases training response but also inflammation.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Muscle building
Training response
Anabolic signaling
Strength

How it works

Prostaglandin precursor
Amplifies exercise inflammatory response
Increases muscle protein synthesis signaling
Works through COX pathway

Dosage

Typical range: 250-500mg daily
Timing: Pre-workout
With food: With fat
Duration: Cycle 4-8 weeks on, 4 weeks off
Special populations: Advanced trainers, those seeking amplified response

Forms

Softgel

Safety

Common side effects

Increased soreness
Inflammation

Contraindications

Inflammatory conditions
Joint issues
Heart disease

Evidence notes

Mechanism makes sense, limited but positive clinical data

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

Related in Performance

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.