Ranked by evidence
Best Gut Health Supplements
The 10 highest-scoring gut health supplements in Formulate's catalog, ranked by the same automated rubric we apply to every product: ingredient dose, bioavailable form, label transparency, safety, and third-party testing. No sponsorships, no pay-to-play.
Scored by the Formulate Research Team · Last reviewed July 2026
- 1
NutricostChicory Root Capsules650mg of Chicory Root Per Capsule 120 Chicory Root Capsules In Each Bottle 1 Serving, Just 1 Capsule (Plant-BasedCapsules) Non-GMO, Vegetarian Friendly, and Gluten Free Made in…
95A - 2
ThorneEnteroMend®Optimal nutritional support for leaky gut* The ingredients in EnteroMend help maintain a healthy gut barrier, soothe mucus membranes, and support a healthy inflammatory and immu…
93A - 3
NutricostBetaine HCI + Pepsin Capsules790mg Of High Quality Betaine HCl + Pepsin Complex 240 Plant-Based Capsules Per Bottle Vegetarian Friendly, Soy Free Non-GMO, 3rd Party Tested Made in a GMP Compliant, FDA Regis…
88A - 4
ThorneBetaine HCL & PepsinBenefits individuals with occasional indigestion* Betaine HCl & Pepsin promotes optimal stomach acidity, protein digestion, and enzyme activity.*
88A - 5
ThorneGI ReliefEase digestive discomfort with GI Relief* A comforting blend of botanical extracts – aloe vera, slippery elm, marshmallow root, and licorice – to calm irritation and soothe the…
88A - 6
ThorneMulti EnzymeA comprehensive digestive enzyme blend of HCl, pepsin, and pancreatin for supporting good digestion* Multi Enzyme combines HCl and pepsin with pancreatic enzymes to promote dige…
87A - 7
ThornePancreatic EnzymesPancreatic enzymes that support digestion and absorption, especially of fats* Digestive enzymes from the pancreas aid with fat, protein, and carb digestion and absorption and pr…
85A- - 8
ThorneAdvanced Digestive EnzymesA digestive enzyme blend that supports individuals who have indigestion or bloating* Advanced Digestive Enzymes promotes the digestion and absorption of proteins, fats, and carb…
84A- - 9
ThorneFiberMendGet a healthy dose of prebiotic fiber for GI wellness and to grow good bacteria in your gut* Keep your gut healthy and in balance with FiberMend, a soluble prebiotic fiber that…
77B+ - 10
ThorneFiberMend®Get a healthy dose of prebiotic fiber for GI wellness and to grow good bacteria in your gut* Keep your gut healthy and in balance with FiberMend, a soluble prebiotic fiber that…
77B+
Frequently asked questions
What is the best gut health supplement?
Nutricost Chicory Root Capsules is Formulate's highest-scoring gut health supplement at 95/100 (grade A). 650mg of Chicory Root Per Capsule 120 Chicory Root Capsules In Each Bottle 1 Serving, Just 1 Capsule (Plant-BasedCapsules) Non-GMO, Vegetarian Friendly, and Gluten Free Made in…
How does Formulate rank gut health supplements?
Each product is scored 0–100 by an automated rubric covering evidence quality, dose accuracy, bioavailable form, label transparency, safety, and manufacturing. Rankings reflect the formula on the label — not advertising or sponsorships.
How many gut health supplements were compared?
This ranking shows the top 10 gut health products Formulate has scored. Browse the full catalog for every product and its breakdown.
Best supplements by category
How these are ranked
Every gut health product is scored on dose accuracy, ingredient form, certifications, transparency, and third-party testing — the same rubric across the whole catalog. See the methodology page for the full breakdown, or browse every supplement.
Educational only. Rankings reflect product formulation quality, not personalized medical advice. Talk to a qualified healthcare provider before starting a new supplement, especially if you take medication.