Ranked by evidence
Best Gut Health Supplements
The 10 highest-scoring gut health supplements in Formulate's catalog, ranked by the same automated rubric we apply to every product: ingredient dose, bioavailable form, label transparency, safety, and third-party testing. No sponsorships, no pay-to-play.
Scored by the Formulate Research Team · Last reviewed July 2026
- 1
ThorneEnteroMend®Optimal nutritional support for leaky gut* The ingredients in EnteroMend help maintain a healthy gut barrier, soothe mucus membranes, and support a healthy inflammatory and immu…
93A - 3
NutricostChicory Root Capsules650mg of Chicory Root Per Capsule 120 Chicory Root Capsules In Each Bottle 1 Serving, Just 1 Capsule (Plant-BasedCapsules) Non-GMO, Vegetarian Friendly, and Gluten Free Made in…
90A - 5
NutricostBetaine HCI + Pepsin Capsules790mg Of High Quality Betaine HCl + Pepsin Complex 240 Plant-Based Capsules Per Bottle Vegetarian Friendly, Soy Free Non-GMO, 3rd Party Tested Made in a GMP Compliant, FDA Regis…
88A - 6
ThorneBetaine HCL & PepsinBenefits individuals with occasional indigestion* Betaine HCl & Pepsin promotes optimal stomach acidity, protein digestion, and enzyme activity.*
88A - 7
ThorneGI ReliefEase digestive discomfort with GI Relief* A comforting blend of botanical extracts – aloe vera, slippery elm, marshmallow root, and licorice – to calm irritation and soothe the…
88A - 8
88A - 9
NutricostBilberry Powder250 Grams of Bilberry Powder Per Bottle Convenient Serving Scoop Included Potent 4:1 Bilberry Extract Powder Non-GMO, Gluten Free, 3rd Party Tested Made in a GMP Compliant, FDA…
87A - 10
ThorneMulti EnzymeA comprehensive digestive enzyme blend of HCl, pepsin, and pancreatin for supporting good digestion* Multi Enzyme combines HCl and pepsin with pancreatic enzymes to promote dige…
87A
Frequently asked questions
What is the best gut health supplement?
Thorne EnteroMend® is Formulate's highest-scoring gut health supplement at 93/100 (grade A). Optimal nutritional support for leaky gut* The ingredients in EnteroMend help maintain a healthy gut barrier, soothe mucus membranes, and support a healthy inflammatory and immu…
How does Formulate rank gut health supplements?
Each product is scored 0–100 by the same automated rubric. Clinical evidence, dose accuracy and bioavailable form carry the score; manufacturing, label transparency and safety are checked separately and can only cost points. Rankings reflect the formula on the label — not advertising or sponsorships.
How many gut health supplements were compared?
This ranking shows the top 10 gut health products Formulate has scored. Browse the full catalog for every product and its breakdown.
Best supplements by category
How these are ranked
Every gut health product is scored on dose accuracy, ingredient form, certifications, transparency, and third-party testing — the same rubric across the whole catalog. See the methodology page for the full breakdown, or browse every supplement.
Educational only. Rankings reflect product formulation quality, not personalized medical advice. Talk to a qualified healthcare provider before starting a new supplement, especially if you take medication.