Ranked by evidence
Best Gut Health Supplements
The 7 highest-scoring gut health supplements in Formulate's catalog, ranked by the same automated rubric we apply to every product: ingredient dose, bioavailable form, label transparency, safety, and third-party testing. No sponsorships, no pay-to-play.
Scored by the Formulate Research Team · Last reviewed May 2026
- 1
ThorneEnteroMend®Optimal nutritional support for leaky gut* The ingredients in EnteroMend help maintain a healthy gut barrier, soothe mucus membranes, and support a healthy inflammatory and immu…
92A - 2
ThorneGI ReliefEase digestive discomfort with GI Relief* A comforting blend of botanical extracts – aloe vera, slippery elm, marshmallow root, and licorice – to calm irritation and soothe the…
87A - 3
ThornePancreatic EnzymesPancreatic enzymes that support digestion and absorption, especially of fats* Digestive enzymes from the pancreas aid with fat, protein, and carb digestion and absorption and pr…
86A- - 4
ThorneBetaine HCL & PepsinBenefits individuals with occasional indigestion* Betaine HCl & Pepsin promotes optimal stomach acidity, protein digestion, and enzyme activity.*
83A- - 5
ThorneAdvanced Digestive EnzymesA digestive enzyme blend that supports individuals who have indigestion or bloating* Advanced Digestive Enzymes promotes the digestion and absorption of proteins, fats, and carb…
82A- - 6
ThorneMulti EnzymeA comprehensive digestive enzyme blend of HCl, pepsin, and pancreatin for supporting good digestion* Multi Enzyme combines HCl and pepsin with pancreatic enzymes to promote dige…
82A- - 7
ThorneFiberMend®Get a healthy dose of prebiotic fiber for GI wellness and to grow good bacteria in your gut* Keep your gut healthy and in balance with FiberMend, a soluble prebiotic fiber that…
76B+
Frequently asked questions
What is the best gut health supplement?
Thorne EnteroMend® is Formulate's highest-scoring gut health supplement at 92/100 (grade A). Optimal nutritional support for leaky gut* The ingredients in EnteroMend help maintain a healthy gut barrier, soothe mucus membranes, and support a healthy inflammatory and immu…
How does Formulate rank gut health supplements?
Each product is scored 0–100 by an automated rubric covering evidence quality, dose accuracy, bioavailable form, label transparency, safety, and manufacturing. Rankings reflect the formula on the label — not advertising or sponsorships.
How many gut health supplements were compared?
This ranking shows the top 7 gut health products Formulate has scored. Browse the full catalog for every product and its breakdown.
Best supplements by category
How these are ranked
Every gut health product is scored on dose accuracy, ingredient form, certifications, transparency, and third-party testing — the same rubric across the whole catalog. See the methodology page for the full breakdown, or browse every supplement.
Educational only. Rankings reflect product formulation quality, not personalized medical advice. Talk to a qualified healthcare provider before starting a new supplement, especially if you take medication.