Statins deplete CoQ10 - supplementation recommended
Statin medications block the same pathway that produces CoQ10, leading to depletion. This may contribute to muscle pain side effects.
Consider CoQ10 supplementation if taking statins.
Can take together; CoQ10 with fatty meal for absorption
Statins deplete CoQ10 - supplementation recommended. Consider CoQ10 supplementation if taking statins.
Can take together; CoQ10 with fatty meal for absorption
This interaction is rated “Synergy” by Formulate. Statin medications block the same pathway that produces CoQ10, leading to depletion. This may contribute to muscle pain side effects.
Studies from our registry that mention coq10 or statins. Each links to the primary source and the other Formulate pages citing it.
Mentions statins · 2019
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia (REDUCE-IT)
Bhatt DL, Steg PG, Miller M, et al. · New England Journal of Medicine
Double-blind RCT (n=8,179) found high-dose EPA (4g/day) reduced ischemic events by 25% vs placebo in patients with elevated triglycerides on statins — the most convincing cardiovascular benefit data for omega-3s.
Mentions coq10 · 2014
The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure (Q-SYMBIO trial)
Mortensen SA, Rosenfeldt F, Kumar A, et al. · JACC: Heart Failure
2-year double-blind multi-center RCT (n=420) in chronic heart failure found 300mg/day CoQ10 (ubiquinone) reduced cardiovascular mortality by 43% and major adverse cardiac events by 50% vs placebo.
Mentions coq10 · 2014
Coenzyme Q10 for heart failure (Cochrane Review)
Madmani ME, Yusuf Solaiman A, Tamr Agha K, et al. · Cochrane Database of Systematic Reviews
Cochrane review of 7 RCTs noted evidence suggests CoQ10 may improve ejection fraction and reduce hospitalization in heart failure, but called for larger long-term trials — Q-SYMBIO partially answered this call.
Other interactions to know
CoQ10 may enhance BP medication effects
Beta blockers may deplete CoQ10
Check your full stack in the free interaction checker.
The free checker lets you add any combination of supplements and medications at once. The free web app goes further — every stack change surfaces interaction alerts automatically.
Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
Last medically reviewed: