Beta blockers may deplete CoQ10
Like statins, some beta blockers (propranolol, metoprolol) can inhibit CoQ10 biosynthesis. Not as well-documented as statin depletion, but supplementation is often considered for long-term users with fatigue.
100-200mg ubiquinol daily is reasonable for long-term beta blocker users — especially if experiencing exercise intolerance.
Take with a fat-containing meal for absorption
Beta blockers may deplete CoQ10. 100-200mg ubiquinol daily is reasonable for long-term beta blocker users — especially if experiencing exercise intolerance.
Take with a fat-containing meal for absorption
This interaction is rated “Info” by Formulate. Like statins, some beta blockers (propranolol, metoprolol) can inhibit CoQ10 biosynthesis. Not as well-documented as statin depletion, but supplementation is often considered for long-term users with fatigue.
Studies from our registry that mention beta blocker or coq10. Each links to the primary source and the other Formulate pages citing it.
Mentions coq10 · 2014
The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure (Q-SYMBIO trial)
Mortensen SA, Rosenfeldt F, Kumar A, et al. · JACC: Heart Failure
2-year double-blind multi-center RCT (n=420) in chronic heart failure found 300mg/day CoQ10 (ubiquinone) reduced cardiovascular mortality by 43% and major adverse cardiac events by 50% vs placebo.
Mentions coq10 · 2014
Coenzyme Q10 for heart failure (Cochrane Review)
Madmani ME, Yusuf Solaiman A, Tamr Agha K, et al. · Cochrane Database of Systematic Reviews
Cochrane review of 7 RCTs noted evidence suggests CoQ10 may improve ejection fraction and reduce hospitalization in heart failure, but called for larger long-term trials — Q-SYMBIO partially answered this call.
Other interactions to know
Statins deplete CoQ10 - supplementation recommended
CoQ10 may enhance BP medication effects
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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
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