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beta blocker and coq10

Beta blockers may deplete CoQ10

What's happening

Like statins, some beta blockers (propranolol, metoprolol) can inhibit CoQ10 biosynthesis. Not as well-documented as statin depletion, but supplementation is often considered for long-term users with fatigue.

Recommendation

100-200mg ubiquinol daily is reasonable for long-term beta blocker users — especially if experiencing exercise intolerance.

Timing

Take with a fat-containing meal for absorption

Sources

  • Biochemical and Biophysical Research Communications
  • PMID: 4146484

Frequently Asked Questions

Can I take beta blocker and coq10 together?

Beta blockers may deplete CoQ10. 100-200mg ubiquinol daily is reasonable for long-term beta blocker users — especially if experiencing exercise intolerance.

How should I time beta blocker and coq10?

Take with a fat-containing meal for absorption

Is this interaction dangerous?

This interaction is rated “Info” by Formulate. Like statins, some beta blockers (propranolol, metoprolol) can inhibit CoQ10 biosynthesis. Not as well-documented as statin depletion, but supplementation is often considered for long-term users with fatigue.

Want to check your whole stack?

The free checker lets you add any combination of supplements and medications at once. Formulate's desktop app goes further — every stack change surfaces interaction alerts automatically.

Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.