Antioxidant
CoQ10 (Ubiquinol)
Also known as: Ubiquinol, Coenzyme Q10, CoQ10, Ubiquinone
Ubiquinol is the active, reduced form of CoQ10, a fat-soluble antioxidant essential for mitochondrial ATP production and cellular energy metabolism. It supports heart health, cellular energy, and may reduce statin-related side effects.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every CoQ10 (Ubiquinol) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nootropics Depot CoQH-CF Softgels | 97 A | $1.00 |
| 2 | Pure Encapsulations Ubiquinol-QH 100 mg | 96 A | $1.65 |
| 3 | Pure Encapsulations Ubiquinol-QH 50 mg | 96 A | $1.06 |
| 4 | Pure Encapsulations Ubiquinol-QH 200 mg | 96 A | $2.87 |
| 5 | Jarrow Formulas QH-absorb - 200mg | 96 A | $1.44 |
| 6 | Jarrow Formulas QH-absorb - 100mg | 96 A | $0.85 |
| 7 | Life Extension Super Ubiquinol CoQ10 | 96 A | $0.63 |
| 8 | NOW Foods Ubiquinol | 95 A | $0.43 |
| 9 | NOW Foods Extra Strength Ubiquinol | 95 A | $0.93 |
| 10 | Jarrow Formulas QH-absorb + PQQ | 93 A | $1.42 |
| 11 | Thorne Omega-3 with CoQ10 | 92 A | $0.61 |
| 12 | Pure Encapsulations SR-CoQ10 with PQQ | 91 A | $3.13 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much CoQ10 (Ubiquinol) should I take?
The typical range is 100–300 mg daily. Effects build over 4–12 weeks; long-term use is safe and appropriate
When should I take CoQ10 (Ubiquinol)?
With meals (fat-soluble; requires dietary fat for absorption). Essential; take with a meal containing fat for optimal bioavailability.
Which form of CoQ10 (Ubiquinol) is best?
Ubiquinol (reduced, active form). Other forms in the catalog: Ubiquinone (oxidized form, less bioavailable).
Is CoQ10 (Ubiquinol) safe?
Commonly reported: Mild gastrointestinal upset (very rare), Insomnia or sleep disturbance (occasional, especially at high doses or late timing), Nausea (minimal).
Which CoQ10 (Ubiquinol) supplement scores highest?
Nootropics Depot CoQH-CF Softgels, at 97/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Cardiovascular health and heart function
- Mitochondrial ATP production and energy
- Antioxidant protection
- Counteracting statin-induced CoQ10 depletion
- Aging and age-related vitality
How it works
- Essential cofactor in the electron transport chain (Complex I–III) for ATP synthesis
- Direct free radical scavenger and antioxidant
- Regenerates vitamin E and other antioxidants
- Supports endothelial function and vascular health
Dosage
- Typical range
- 100–300 mg daily
- Timing
- With meals (fat-soluble; requires dietary fat for absorption)
- With food
- Essential; take with a meal containing fat for optimal bioavailability
- Duration
- Effects build over 4–12 weeks; long-term use is safe and appropriate
- Special populations
- Statin users: 100–200 mg daily recommended to replenish depleted levels; elderly may benefit from higher doses due to age-related decline
Forms
- Ubiquinol (reduced, active form)· 70/100
- Ubiquinone (oxidized form, less bioavailable)· 70/100
Safety
Common side effects
- Mild gastrointestinal upset (very rare)
- Insomnia or sleep disturbance (occasional, especially at high doses or late timing)
- Nausea (minimal)
Contraindications
- None known; well-tolerated across populations
- Caution in blood-clotting disorders (minor vitamin K-like activity)
Products containing CoQ10 (Ubiquinol)
Top-scoring supplements in our catalog that list CoQ10 (Ubiquinol) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Strong evidence for cardiovascular benefit (especially heart failure and hypertension); well-established ATP production role; ubiquinol form shows superior bioavailability vs. ubiquinone; statin interaction supported by multiple RCTs.
Grade B: Some human trials support key claims; further confirmation needed.
Cited research for CoQ10 (Ubiquinol)
Clinical studies referenced across Formulate guides that mention coq10 (ubiquinol). Each links to the full study page with PubMed source + the guides that cite it.
- Mortensen SA, Rosenfeldt F, Kumar A, et al. (2014)JACC: Heart Failure
The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure (Q-SYMBIO trial)
- Madmani ME, Yusuf Solaiman A, Tamr Agha K, et al. (2014)Cochrane Database of Systematic Reviews
Coenzyme Q10 for heart failure (Cochrane Review)
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.