Chromium adds to metformin's glucose-lowering effect
Both chromium and metformin improve insulin sensitivity. Combination may cause hypoglycemia, especially if reducing carbohydrate intake simultaneously.
Monitor blood sugar. Generally safe but watch for hypoglycemia symptoms.
Monitor glucose levels, especially before meals
Chromium adds to metformin's glucose-lowering effect. Monitor blood sugar. Generally safe but watch for hypoglycemia symptoms.
Monitor glucose levels, especially before meals
This interaction is rated “Caution” by Formulate. Both chromium and metformin improve insulin sensitivity. Combination may cause hypoglycemia, especially if reducing carbohydrate intake simultaneously.
Studies from our registry that mention chromium or metformin. Each links to the primary source and the other Formulate pages citing it.
Other interactions to know
Chromium may enhance insulin sensitivity
Berberine has metformin-like glucose lowering
Check your full stack in the free interaction checker.
The free checker lets you add any combination of supplements and medications at once. The free web app goes further — every stack change surfaces interaction alerts automatically.
Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
Last medically reviewed: