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antibiotics and probiotics

Antibiotics kill probiotic bacteria if taken together

What's happening

Oral antibiotics will kill live probiotic organisms if taken at the same time, making the probiotic useless. Spacing them out preserves both.

Recommendation

Continue probiotics during an antibiotic course — they reduce antibiotic-associated diarrhea. Take the probiotic 2-3 hours after the antibiotic dose.

Timing

Separate by at least 2-3 hours; continue for 2+ weeks after finishing antibiotics

Sources

  • Cochrane Review 2017
  • PMID: 29257353

Frequently Asked Questions

Can I take antibiotics and probiotics together?

Antibiotics kill probiotic bacteria if taken together. Continue probiotics during an antibiotic course — they reduce antibiotic-associated diarrhea. Take the probiotic 2-3 hours after the antibiotic dose.

How should I time antibiotics and probiotics?

Separate by at least 2-3 hours; continue for 2+ weeks after finishing antibiotics

Is this interaction dangerous?

This interaction is rated “Caution” by Formulate. Oral antibiotics will kill live probiotic organisms if taken at the same time, making the probiotic useless. Spacing them out preserves both.

Want to check your whole stack?

The free checker lets you add any combination of supplements and medications at once. Formulate's desktop app goes further — every stack change surfaces interaction alerts automatically.

Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.