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Herbal Extract

Trigonella foenum-graecum Extract (Seed)

Also known as: Fenugreek Extract, Methi Extract, 4-Hydroxyisoleucine Source

B
Evidence

A seed extract containing trigonelline and protodioscin with traditional use for hormonal health, lactation support, and blood sugar management. Moderate evidence supports some metabolic applications.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Blood glucose regulation
  • Testosterone and sexual function (claimed)
  • Lactation support
  • Inflammation reduction

How it works

  • 4-Hydroxyisoleucine (soluble fiber component) improves insulin sensitivity
  • Trigonelline may have neuroprotective properties
  • Protodioscin content provides hormonal support (limited evidence)

Dosage

Typical range
500-1000 mg daily of standardized extract (or 1-5g whole seed)
Timing
With meals for blood sugar; flexible for other uses
With food
Recommended for GI tolerance and absorption
Duration
4-8 weeks for glycemic effects; lactation benefits within days
Special populations
Generally safe in pregnancy for lactation support (consult provider); monitor glucose if diabetic

Forms

  • Seed Extract (3% Trigonelline, 1% Protodioscin)· 70/100

Safety

Common side effects

  • Maple-like body odor
  • Gastrointestinal upset, diarrhea
  • Abdominal discomfort
  • Allergic reactions (rare; cross-reactivity with peanuts/chickpeas)

Contraindications

  • Peanut allergy (potential cross-reactivity)
  • Uncontrolled hypoglycemia
  • Bleeding disorders (coumarin content)

Evidence notes

Good evidence for blood sugar and lactation support; moderate clinical trial data. Sexual function claims have less robust support. Well-studied for glycemic effects.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.