Methylation
TMG (Trimethylglycine/Betaine)
Also known as: Betaine anhydrous, Trimethylglycine, Betaine HCl is different
Methyl donor supporting homocysteine metabolism and methylation. Important cofactor when taking NAD+ precursors that consume methyl groups.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every TMG (Trimethylglycine/Betaine) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Thorne Methyl-Guard® | 93 A | $0.93 |
| 2 | Nutricost TMG Capsules | 92 A | $0.10 |
| 3 | Nutricost Betaine Anhydrous (TMG) Capsules | 91 A | $0.18 |
| 4 | Thorne Methyl-Guard Plus | 91 A | $2.07 |
| 5 | Transparent Labs BULK Pre-Workout | 90 A | $1.67 |
| 6 | Nutricost Pre-Workout For Women Powder | 89 A | $0.73 |
| 7 | Nutricost Pre-Workout Complex | 89 A | $0.83 |
| 8 | Thorne SynaQuell +™ | 88 A | $1.47 |
| 9 | Thorne MediClear-SGS™ - Vanilla | 86 A- | $2.10 |
| 10 | Thorne Brain Factors | 84 A- | $1.70 |
| 11 | Thorne ResveraCel | 84 A- | $2.00 |
| 12 | Pure Encapsulations Homocysteine Factors | 83 A- | $0.38 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much TMG (Trimethylglycine/Betaine) should I take?
The typical range is 500-3000mg daily. Safe long-term
When should I take TMG (Trimethylglycine/Betaine)?
With NAD+ precursors or meals. Optional.
Which form of TMG (Trimethylglycine/Betaine) is best?
Powder — Most economical. Other forms in the catalog: Capsule.
Is TMG (Trimethylglycine/Betaine) safe?
Commonly reported: GI upset, Fishy odor at high doses. Serious warnings: May raise LDL in some. Hepatoprotective
Which TMG (Trimethylglycine/Betaine) supplement scores highest?
Thorne Methyl-Guard®, at 93/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Methylation support
- Homocysteine metabolism
- NAD+ precursor support
- Liver health
How it works
- Donates methyl groups
- Supports homocysteine remethylation
- Osmolyte function
- Liver protective
Dosage
- Typical range
- 500-3000mg daily
- Timing
- With NAD+ precursors or meals
- With food
- Optional
- Duration
- Safe long-term
- Special populations
- NAD+ precursor users, MTHFR variants, high homocysteine
Forms
- Powder
- Capsule
Safety
Common side effects
- GI upset
- Fishy odor at high doses
Contraindications
- None significant
Products containing TMG (Trimethylglycine/Betaine)
Top-scoring supplements in our catalog that list TMG (Trimethylglycine/Betaine) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Well-established for homocysteine and methylation support
Grade A: Multiple well-designed human trials support the main claims.
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does TMG (Trimethylglycine/Betaine) fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.