Methylation

TMG (Trimethylglycine/Betaine)

Also known as: Betaine anhydrous, Trimethylglycine, Betaine HCl is different

Evidence

Methyl donor supporting homocysteine metabolism and methylation. Important cofactor when taking NAD+ precursors that consume methyl groups.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Methylation support
Homocysteine metabolism
NAD+ precursor support
Liver health

How it works

Donates methyl groups
Supports homocysteine remethylation
Osmolyte function
Liver protective

Dosage

Typical range: 500-3000mg daily
Timing: With NAD+ precursors or meals
With food: Optional
Duration: Safe long-term
Special populations: NAD+ precursor users, MTHFR variants, high homocysteine

Forms

Powder
Capsule

Safety

Common side effects

GI upset
Fishy odor at high doses

Contraindications

None significant

Products containing TMG (Trimethylglycine/Betaine)

Top-scoring supplements in our catalog that list TMG (Trimethylglycine/Betaine) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne

Methyl-Guard®

Nutricost

Betaine Anhydrous (TMG) Capsules

Evidence notes

Well-established for homocysteine and methylation support

Grade A: Multiple well-designed human trials support the main claims.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.