Methylation
TMG (Trimethylglycine/Betaine)
Also known as: Betaine anhydrous, Trimethylglycine, Betaine HCl is different
A
Evidence
Methyl donor supporting homocysteine metabolism and methylation. Important cofactor when taking NAD+ precursors that consume methyl groups.
Primary uses
- Methylation support
- Homocysteine metabolism
- NAD+ precursor support
- Liver health
How it works
- Donates methyl groups
- Supports homocysteine remethylation
- Osmolyte function
- Liver protective
Dosage
- Typical range
- 500-3000mg daily
- Timing
- With NAD+ precursors or meals
- With food
- Optional
- Duration
- Safe long-term
- Special populations
- NAD+ precursor users, MTHFR variants, high homocysteine
Forms
- Powder
- Capsule
Safety
Common side effects
- GI upset
- Fishy odor at high doses
Contraindications
- None significant
Evidence notes
Well-established for homocysteine and methylation support
Grade A: Multiple well-designed human trials support the main claims.
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