Skip to main content

Probiotic

Saccharomyces boulardii

Also known as: CNCM I-745, Florastor, S. boulardii

A
Evidence

Beneficial yeast probiotic that's antibiotic-resistant. Excellent for diarrhea, C. diff, and antibiotic support.

Find the best Saccharomyces boulardii supplements — free
See Saccharomyces boulardii products scored on dose & form, then track your intake in the app.
Open app →

Primary uses

  • Diarrhea
  • Antibiotic support
  • C. diff prevention
  • Traveler's diarrhea

How it works

  • Not killed by antibiotics
  • Secretes anti-toxin factors
  • Supports gut barrier

Dosage

Typical range
250-500 mg (5-10 billion cells) daily
Timing
During and after antibiotics
With food
Either way
Duration
During infection/antibiotics and 2 weeks after
Special populations
Antibiotic users, recurrent C. diff

Forms

  • Capsules

Safety

Common side effects

  • Gas
  • Bloating

Contraindications

  • Central venous catheter
  • Severe immunocompromise

Products containing Saccharomyces boulardii

Top-scoring supplements in our catalog that list Saccharomyces boulardii on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne
Sacro-B™
68
See all products →

Known interactions

Evidence notes

Strong evidence for diarrhea prevention

Grade A: Multiple well-designed human trials support the main claims.

Cited research for Saccharomyces boulardii

Clinical studies referenced across Formulate guides that mention saccharomyces boulardii. Each links to the full study page with PubMed source + the guides that cite it.

Related in Probiotic

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.