Skip to main content

Vitamin

Pyridoxal 5'-Phosphate

Also known as: P5P, Pyridoxal phosphate, Vitamin B6 active form, 5'-phosphate of pyridoxal

A
Evidence

The active coenzyme form of vitamin B6, directly utilized in amino acid metabolism, neurotransmitter synthesis, and immune function without requiring hepatic conversion.

Primary uses

  • Amino acid metabolism
  • Neurotransmitter synthesis (serotonin, dopamine, GABA)
  • Immune function support
  • Homocysteine metabolism

How it works

  • Coenzyme in aminotransferase reactions
  • Cofactor for neurotransmitter synthesis
  • Support for one-carbon metabolism
  • Immune cell differentiation and function

Dosage

Typical range
25-100 mg daily
Timing
Morning with breakfast recommended
With food
Take with food for optimal absorption
Duration
Safe for long-term daily use; effects accumulate over time
Special populations
Safe in pregnancy (supports fetal development); safe for all ages at recommended doses

Forms

  • Capsule· 70/100
  • Tablet· 70/100
  • Powder· 70/100

Safety

Common side effects

  • Rare at typical doses; very well tolerated

Evidence notes

Well-established biochemical role as active B6 form. Strong evidence for deficiency correction and role in disease prevention. Bioavailable and effective in clinical settings.

Grade A: Multiple well-designed human trials support the main claims.

Related in Vitamin

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.