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Vitamin

Pyridoxal 5'-Phosphate

Also known as: P5P, Pyridoxal phosphate, Vitamin B6 active form, 5'-phosphate of pyridoxal

A
Evidence

The active coenzyme form of vitamin B6, directly utilized in amino acid metabolism, neurotransmitter synthesis, and immune function without requiring hepatic conversion.

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Daily target & upper limit

1.7 mg / day · UL 100 mg

Pyridoxal 5'-Phosphate has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

Pyridoxal 5'-Phosphate dosage reference →

Primary uses

  • Amino acid metabolism
  • Neurotransmitter synthesis (serotonin, dopamine, GABA)
  • Immune function support
  • Homocysteine metabolism

How it works

  • Coenzyme in aminotransferase reactions
  • Cofactor for neurotransmitter synthesis
  • Support for one-carbon metabolism
  • Immune cell differentiation and function

Dosage

Typical range
25-100 mg daily
Timing
Morning with breakfast recommended
With food
Take with food for optimal absorption
Duration
Safe for long-term daily use; effects accumulate over time
Special populations
Safe in pregnancy (supports fetal development); safe for all ages at recommended doses

Forms

  • Capsule· 70/100
  • Tablet· 70/100
  • Powder· 70/100

Safety

Common side effects

  • Rare at typical doses; very well tolerated

Products containing Pyridoxal 5'-Phosphate

Top-scoring supplements in our catalog that list Pyridoxal 5'-Phosphate on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Nootropics Depot
Alcohol Defense Capsule
76
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Evidence notes

Well-established biochemical role as active B6 form. Strong evidence for deficiency correction and role in disease prevention. Bioavailable and effective in clinical settings.

Grade A: Multiple well-designed human trials support the main claims.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.