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Antioxidant

Pycnogenol (Prelox for ED)

Also known as: Pine bark extract, French maritime pine, Prelox component

B
Evidence

Pine bark extract that with L-Arginine (Prelox) has evidence for erectile dysfunction.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Erectile dysfunction
  • Endothelial function
  • Blood flow
  • Antioxidant

How it works

  • Enhances nitric oxide production
  • Antioxidant for endothelium
  • Prelox formula studied for ED
  • Supports blood vessel health

Dosage

Typical range
40-120mg Pycnogenol + 1.7g L-Arginine (Prelox dosing)
Timing
Divided doses
With food
Either way
Duration
1-3 months for ED improvement
Special populations
Mild-moderate ED, endothelial dysfunction

Forms

  • Pycnogenol extract
  • Prelox formula

Safety

Common side effects

  • GI upset
  • Dizziness
  • Headache

Contraindications

  • Autoimmune conditions (immunomodulating)

Products containing Pycnogenol (Prelox for ED)

Top-scoring supplements in our catalog that list Pycnogenol (Prelox for ED) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne
Meta-Balance™
90
See all products →

Evidence notes

Good evidence when combined with L-Arginine (Prelox)

Grade B: Some human trials support key claims; further confirmation needed.

Related in Antioxidant

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.