Nootropic
Nefiracetam
Also known as: DM-9384
Fat-soluble racetam with unique GABAergic effects. Enhances long-term potentiation.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Memory
- Mood
- Neuroprotection
- Apathy
How it works
- Enhances GABAergic signaling
- Calcium channel modulation
- Long-term potentiation enhancement
Dosage
- Typical range
- 400-800 mg daily divided
- Timing
- With fatty meals
- With food
- Yes, essential
- Duration
- Cumulative benefits
- Special populations
- Memory, apathy
Forms
- Capsules
- Powder
Safety
Common side effects
- Headache
- GI upset
Contraindications
- Unknown
Evidence notes
Unique GABAergic racetam
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.