Amino Acid

N-Acetyl Cysteine (Fertility)

Evidence

Antioxidant that supports glutathione, may help PCOS and male fertility.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

PCOS
Ovulation
Sperm quality
Antioxidant

How it works

Glutathione precursor
Antioxidant for reproductive tissues
May support ovulation in PCOS
May improve sperm quality

Dosage

Typical range: 600-1800mg daily
Timing: Divided doses, away from meals
With food: Away from food for best absorption
Duration: 3 months before conception
Special populations: PCOS, male fertility, antioxidant support

Forms

Capsules
Powder
Sustained-release

Safety

Common side effects

GI upset
Sulfur odor
Nausea

Contraindications

Active bleeding
With nitroglycerin

Evidence notes

Good evidence for PCOS ovulation and male fertility

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.