Joint Health
MSM (Methylsulfonylmethane)
Also known as: Methylsulfonylmethane, Dimethyl sulfone
Organic sulfur compound supporting joint tissue, connective tissue, and reducing inflammation.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Joint health
- Inflammation
- Connective tissue
- Hair/skin/nails
How it works
- Sulfur donor for connective tissue
- Anti-inflammatory
- May reduce oxidative stress
Dosage
- Typical range
- 1-3g daily
- Timing
- Any time
- With food
- Optional
- Duration
- Safe long-term
- Special populations
- Joint issues, athletes
Forms
- Powder
- Capsules
- Cream
Safety
Common side effects
- Mild GI upset
- Headache initially
Contraindications
- None
Evidence notes
Good safety profile, moderate evidence
Grade B: Some human trials support key claims; further confirmation needed.
Related in Joint Health
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.