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Fatty Acid

GLA (Evening Primrose Oil)

Also known as: Evening primrose oil, EPO, Gamma-linolenic acid

B
Evidence

Gamma-linolenic acid omega-6 for skin health, PMS, and inflammation. Anti-inflammatory despite being omega-6.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Skin health
  • PMS symptoms
  • Inflammation
  • Hormone balance

How it works

  • GLA converts to anti-inflammatory DGLA
  • Supports skin barrier
  • May help PMS symptoms

Dosage

Typical range
500-3000 mg EPO daily (providing 40-300mg GLA)
Timing
With meals
With food
Yes
Duration
Benefits develop over weeks
Special populations
PMS, eczema, skin concerns

Forms

  • Softgel
  • Oil

Safety

Common side effects

  • GI upset
  • Headache

Contraindications

  • Seizure disorders
  • Before surgery

Evidence notes

Anti-inflammatory omega-6

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.