Herbal Extract

Cat's Claw Extract (Uncaria tomentosa)

Also known as: Una de Gato, Uncaria tomentosa, Cat's Claw, Vilcacora

Evidence

Cat's Claw is a Peruvian vine traditionally used to support immune function and joint health, containing alkaloids and polyphenols with preliminary anti-inflammatory properties. Evidence remains moderate and primarily from in vitro and animal studies, with limited high-quality human clinical trials.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Immune system support
Joint health and flexibility
Anti-inflammatory support
General wellness

How it works

Contains pentacyclic oxindole alkaloids that may modulate immune response
Polyphenol content provides antioxidant activity
May reduce pro-inflammatory cytokine production

Dosage

Typical range: 400-1000 mg daily (or 20-60 mg of 10:1 extract equivalent)
Timing: With meals for better tolerance
With food: Recommended to minimize gastrointestinal upset
Duration: Some studies used 12-24 week protocols; long-term safety data limited
Special populations: Avoid during pregnancy/lactation; caution in autoimmune conditions

Forms

Extract (10:1)· 70/100
Capsules· 70/100
Powder· 70/100
Liquid extract· 70/100

Safety

Common side effects

Nausea
Dizziness
Headache
Gastrointestinal upset

Contraindications

Pregnancy and lactation
Autoimmune diseases (may overstimulate immune response)
Bleeding disorders or anticoagulant use (theoretical risk)
Recent organ transplant

Evidence notes

Moderate evidence from small human trials and traditional use; most mechanistic evidence is in vitro or animal-derived. Limited large-scale RCTs in humans. 10:1 extract represents concentrated form but lacks standardized clinical evidence specific to this ratio.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.