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Herbal Extract

Goldenseal Root Powder

Also known as: Hydrastis canadensis, Goldenseal, Hydrastis, Yellow root

C
Evidence

Goldenseal is a traditional North American herb traditionally used for immune support and digestive health, containing the alkaloid berberine as its primary active compound. Clinical evidence for efficacy is limited and inconsistent, with most studies examining berberine rather than goldenseal extract directly.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Immune support
  • Upper respiratory health
  • Digestive support
  • Traditional use for infection

How it works

  • Berberine-mediated antimicrobial activity (in vitro)
  • Potential immunomodulation
  • Traditional use for mucous membrane support

Dosage

Typical range
500–1000 mg daily (as dried root powder)
Timing
With meals
With food
Recommended with food to minimize digestive upset
Duration
Traditional use suggests short-term use (2–4 weeks); long-term safety data limited
Special populations
Avoid during pregnancy/lactation and in infants; use cautiously with hepatic impairment

Forms

  • Powder· 70/100
  • Capsule· 70/100
  • Extract· 70/100
  • Tincture· 70/100

Safety

Common side effects

  • Digestive upset
  • Nausea
  • Constipation
  • Altered gut flora (with prolonged use)

Contraindications

  • Pregnancy and lactation
  • Infants and young children
  • Hyperbilirubinemia (elevated bilirubin)
  • Significant hepatic disease
  • G6PD deficiency

Evidence notes

Limited human clinical trials specific to goldenseal root. Most evidence is traditional use, in vitro antimicrobial data, or studies on isolated berberine. Lacks robust RCT evidence for primary claimed uses.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.