Antioxidant
Calebin-A (CurCousin®)
Also known as: Calebin A, 4-Methylcurcumin, curcumin derivative
A proprietary curcumin analog (98% Calebin-A) derived from turmeric with enhanced bioavailability and potential metabolic properties distinct from standard curcumin. An emerging derivative researched for inflammation and cellular health.
Primary uses
- Antioxidant support
- Inflammation modulation
- Cellular health
- Metabolic support
How it works
- NF-κB pathway inhibition
- Antioxidant/free radical scavenging
- Mitochondrial function support
- Microsomal stability (superior to standard curcumin)
Dosage
- Typical range
- 150-400 mg daily
- Timing
- With meals and fat sources
- With food
- Essential; fat-soluble and requires dietary lipids for absorption
- Duration
- Continuous use recommended; effects typically develop over 4-12 weeks
- Special populations
- Pregnancy/nursing: avoid; gallbladder disease: consult provider; anticoagulant users: monitor
Forms
- 98% Calebin-A standardized extract· 70/100
Safety
Common side effects
- Gastrointestinal upset (mild)
- Staining of teeth or tongue (turmeric-related)
Contraindications
- Pregnancy and breastfeeding
- Biliary obstruction or severe gallbladder disease
- High-dose use with anticoagulants
Evidence notes
Preliminary and emerging data on Calebin-A; in vitro and animal studies show promise; very limited human clinical trial data compared to standard curcumin; bioavailability advantage over curcumin is proposed but human evidence is sparse.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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