Antioxidant
Calebin-A (CurCousin®)
Also known as: Calebin A, 4-Methylcurcumin, curcumin derivative
A proprietary curcumin analog (98% Calebin-A) derived from turmeric with enhanced bioavailability and potential metabolic properties distinct from standard curcumin. An emerging derivative researched for inflammation and cellular health.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Antioxidant support
- Inflammation modulation
- Cellular health
- Metabolic support
How it works
- NF-κB pathway inhibition
- Antioxidant/free radical scavenging
- Mitochondrial function support
- Microsomal stability (superior to standard curcumin)
Dosage
- Typical range
- 150-400 mg daily
- Timing
- With meals and fat sources
- With food
- Essential; fat-soluble and requires dietary lipids for absorption
- Duration
- Continuous use recommended; effects typically develop over 4-12 weeks
- Special populations
- Pregnancy/nursing: avoid; gallbladder disease: consult provider; anticoagulant users: monitor
Forms
- 98% Calebin-A standardized extract· 70/100
Safety
Common side effects
- Gastrointestinal upset (mild)
- Staining of teeth or tongue (turmeric-related)
Contraindications
- Pregnancy and breastfeeding
- Biliary obstruction or severe gallbladder disease
- High-dose use with anticoagulants
Evidence notes
Preliminary and emerging data on Calebin-A; in vitro and animal studies show promise; very limited human clinical trial data compared to standard curcumin; bioavailability advantage over curcumin is proposed but human evidence is sparse.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Antioxidant
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does Calebin-A (CurCousin®) fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.