Vitamin
Benfotiamine
Also known as: Lipid-soluble thiamine, S-benzoylthiamine
Fat-soluble thiamine derivative with superior bioavailability. Particularly effective for diabetic neuropathy and AGE reduction.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Benfotiamine product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nutricost Benfotiamine (300 MG) (90 Caps) | 93 A | $0.20 |
| 2 | Nutricost Benfotiamine (600 mg) 180 Capsules | 93 A | $0.24 |
| 3 | Life Extension Mitochondrial Energy Optimizer with PQQ | 90 A | $1.63 |
| 4 | Double Wood Benfotiamine Supplement | 89 A | $0.33 |
| 5 | Pure Encapsulations MethylAssist | 83 A- | $0.71 |
| 6 | Pure Encapsulations PureGenomics B-Complex | 80 A- | $0.39 |
| 7 | Pure Encapsulations PureGenomics Multivitamin | 80 A- | $0.77 |
| 8 | Carlson Active B Complex | 76 B+ | $0.37 |
| 9 | Doctor's Best Benfotiamine with BenfoPure, 300 mg, 60 Veggie Caps | 75 B+ | $0.32 |
| 10 | Doctor's Best Benfotiamine 150 with BenfoPure, 150 mg, 120 Veggie Caps | 75 B+ | $0.17 |
| 11 | Doctor's Best Benfotiamine 150 + Alpha-Lipoic Acid 300, 60 Veggie Caps | 75 B+ | $0.33 |
| 12 | Doctor's Best Benfotiamine with BenfoPure, 150 mg, 360 Veggie Caps | 75 B+ | $0.12 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Benfotiamine should I take?
The typical range is 150-600 mg daily. Benefits develop over weeks
When should I take Benfotiamine?
With meals. Yes.
Which form of Benfotiamine is best?
Capsule — Standard form.
Is Benfotiamine safe?
Commonly reported: Well tolerated. Serious warnings: None known. May be beneficial in diabetes
Which Benfotiamine supplement scores highest?
Nutricost Benfotiamine (300 MG) (90 Caps), at 93/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Daily target & upper limit
1.2 mg / dayBenfotiamine has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:
Benfotiamine dosage reference →Primary uses
- Diabetic neuropathy
- AGE reduction
- Nerve health
- Blood sugar support
How it works
- 5x better absorbed than thiamine
- Blocks AGE formation
- Activates transketolase
- Protects endothelial cells
Dosage
- Typical range
- 150-600 mg daily
- Timing
- With meals
- With food
- Yes
- Duration
- Benefits develop over weeks
- Special populations
- Diabetics, neuropathy
Forms
- Capsule
Safety
Common side effects
- Well tolerated
Contraindications
- None
Products containing Benfotiamine
Top-scoring supplements in our catalog that list Benfotiamine on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Superior bioavailability for neuropathy
Grade B: Some human trials support key claims; further confirmation needed.
Related in Vitamin
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does Benfotiamine fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.