Vitamin
Benfotiamine
Also known as: Lipid-soluble thiamine, S-benzoylthiamine
Fat-soluble thiamine derivative with superior bioavailability. Particularly effective for diabetic neuropathy and AGE reduction.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Daily target & upper limit
1.2 mg / dayBenfotiamine has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:
Benfotiamine dosage reference →Primary uses
- Diabetic neuropathy
- AGE reduction
- Nerve health
- Blood sugar support
How it works
- 5x better absorbed than thiamine
- Blocks AGE formation
- Activates transketolase
- Protects endothelial cells
Dosage
- Typical range
- 150-600 mg daily
- Timing
- With meals
- With food
- Yes
- Duration
- Benefits develop over weeks
- Special populations
- Diabetics, neuropathy
Forms
- Capsule
Safety
Common side effects
- Well tolerated
Contraindications
- None
Products containing Benfotiamine
Top-scoring supplements in our catalog that list Benfotiamine on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Superior bioavailability for neuropathy
Grade B: Some human trials support key claims; further confirmation needed.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.