Mushroom
Turkey Tail (Trametes versicolor)
Also known as: Trametes versicolor, Coriolus versicolor, PSK, PSP
Most-researched medicinal mushroom for immune support, particularly studied as adjunct in cancer care.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Immune support
- Gut microbiome
- Cancer adjunct
- Respiratory health
How it works
- PSK and PSP are potent immunomodulators
- Enhances T-cell and NK cell activity
- Supports gut microbiome diversity
- Used as cancer adjunct in Japan
Dosage
- Typical range
- 1-3g extract or 2-6g powder daily
- Timing
- Any time
- With food
- Either way
- Duration
- Long-term use studied
- Special populations
- Those seeking immune support, cancer adjunct therapy (with oncologist)
Forms
- Hot water extract
- Dual extract
- PSK extract
- Powder
Safety
Common side effects
- Rare: darkened stools
- Mild GI upset
Contraindications
- Autoimmune diseases
- Immunosuppressant use (consult doctor)
Evidence notes
Strong research especially for immune modulation
Grade A: Multiple well-designed human trials support the main claims.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.