Antioxidant
Sesanum indicum Extract (Sesame Seed) - 70% Sesamins
Also known as: sesame seed extract, sesamins, sesamin, sesamol
Sesame seed extract standardized to 70% sesamins is a lignan-rich antioxidant derived from sesame seeds with preliminary evidence for antioxidant and anti-inflammatory effects. Human clinical research remains limited, with most supportive data from in vitro and animal studies.
Primary uses
- Antioxidant support
- Anti-inflammatory support
- Cognitive function
- Cardiovascular health
- Cholesterol management
How it works
- Lignan-based antioxidant activity via free radical scavenging
- CYP3A4 and CYP2C9 enzyme modulation
- Anti-inflammatory signaling pathway support
- Lipid peroxidation reduction
Dosage
- Typical range
- 300-600 mg daily (standardized to 70% sesamins)
- Timing
- With meals for optimal absorption
- With food
- Recommended; sesamins are fat-soluble compounds
- Duration
- No established minimum duration; effects may take 4-8 weeks to manifest
- Special populations
- Pregnant/nursing women should consult healthcare provider; limited safety data in pediatric populations
Forms
- Powder· 70/100
- Capsule· 70/100
- Extract· 70/100
Safety
Common side effects
- Generally well-tolerated
- Rare: gastrointestinal upset
- Rare: allergic reactions (sesame allergy)
Contraindications
- Sesame allergy or sensitivity
- Concurrent use with immunosuppressants (potential sesame immunogenicity)
Evidence notes
Limited human RCT evidence; most studies are in vitro or animal models. A few small human studies show modest benefits for antioxidant status and lipid profiles, but robust clinical efficacy data is lacking. Standardization to sesamins is appropriate, but clinical outcomes require additional investigation.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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