Herbal Extract
Salvia officinalis Extract (Sage Leaf)
Also known as: Siberius™, Common Sage Extract, Garden Sage Extract, Sage Leaf Extract
Salvia officinalis (common sage) leaf extract standardized to rosmarinic acid has been traditionally used to support cognitive function and memory, with emerging evidence suggesting antioxidant and anti-inflammatory properties relevant to neuroprotection.
Primary uses
- Cognitive support
- Memory enhancement
- Antioxidant support
- Neuroprotection
How it works
- Rosmarinic acid provides antioxidant and anti-inflammatory effects
- May inhibit acetylcholinesterase, supporting cholinergic signaling
- Polyphenol-mediated neuroprotection against oxidative stress
Dosage
- Typical range
- 300-600 mg daily (of standardized extract)
- Timing
- Morning or with meals
- With food
- May be taken with or without food; rosmarinic acid absorption may be improved with dietary fat
- Duration
- Safe for long-term use; benefits may develop over 4-8 weeks of consistent use
- Special populations
- Generally well-tolerated; limited safety data in pregnancy and lactation—use with caution or avoid
Forms
- Capsule· 70/100
- Standardized extract powder· 70/100
Safety
Common side effects
- Rare; generally well-tolerated at recommended doses
- Possible mild gastrointestinal effects or headache in sensitive individuals
Contraindications
- Pregnancy and lactation (insufficient safety data)
- Individuals with seizure disorders (sage may have proconvulsant properties at very high doses)
- Those with thujone sensitivity (traditional sage contains low levels of thujone)
Evidence notes
Sage extract has moderate traditional use and some clinical studies support cognitive benefits, but high-quality RCT evidence in humans remains limited. Rosmarinic acid standardization is favorable for consistency, but the body of evidence is not yet robust enough for grade B.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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