Herbal Extract
Salvia officinalis Extract (Sage Leaf)
Also known as: Siberius™, Common Sage Extract, Garden Sage Extract, Sage Leaf Extract
Salvia officinalis (common sage) leaf extract standardized to rosmarinic acid has been traditionally used to support cognitive function and memory, with emerging evidence suggesting antioxidant and anti-inflammatory properties relevant to neuroprotection.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Salvia officinalis Extract (Sage Leaf) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Pure Encapsulations PhytoBalance II | 82 A- | $0.47 |
| 2 | Vital Nutrients Menopause Support | 74 B+ | $0.70 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Salvia officinalis Extract (Sage Leaf) should I take?
The typical range is 300-600 mg daily (of standardized extract). Safe for long-term use; benefits may develop over 4-8 weeks of consistent use
When should I take Salvia officinalis Extract (Sage Leaf)?
Morning or with meals. May be taken with or without food; rosmarinic acid absorption may be improved with dietary fat.
Which form of Salvia officinalis Extract (Sage Leaf) is best?
Capsule. Other forms in the catalog: Standardized extract powder.
Is Salvia officinalis Extract (Sage Leaf) safe?
Commonly reported: Rare; generally well-tolerated at recommended doses, Possible mild gastrointestinal effects or headache in sensitive individuals.
Which Salvia officinalis Extract (Sage Leaf) supplement scores highest?
Pure Encapsulations PhytoBalance II, at 82/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Cognitive support
- Memory enhancement
- Antioxidant support
- Neuroprotection
How it works
- Rosmarinic acid provides antioxidant and anti-inflammatory effects
- May inhibit acetylcholinesterase, supporting cholinergic signaling
- Polyphenol-mediated neuroprotection against oxidative stress
Dosage
- Typical range
- 300-600 mg daily (of standardized extract)
- Timing
- Morning or with meals
- With food
- May be taken with or without food; rosmarinic acid absorption may be improved with dietary fat
- Duration
- Safe for long-term use; benefits may develop over 4-8 weeks of consistent use
- Special populations
- Generally well-tolerated; limited safety data in pregnancy and lactation—use with caution or avoid
Forms
- Capsule· 70/100
- Standardized extract powder· 70/100
Safety
Common side effects
- Rare; generally well-tolerated at recommended doses
- Possible mild gastrointestinal effects or headache in sensitive individuals
Contraindications
- Pregnancy and lactation (insufficient safety data)
- Individuals with seizure disorders (sage may have proconvulsant properties at very high doses)
- Those with thujone sensitivity (traditional sage contains low levels of thujone)
Products containing Salvia officinalis Extract (Sage Leaf)
Top-scoring supplements in our catalog that list Salvia officinalis Extract (Sage Leaf) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Sage extract has moderate traditional use and some clinical studies support cognitive benefits, but high-quality RCT evidence in humans remains limited. Rosmarinic acid standardization is favorable for consistency, but the body of evidence is not yet robust enough for grade B.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Herbal Extract
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.