Herbal Extract
Rutaecarpine
Also known as: 1-methoxychelerythrine, rutamarin
Rutaecarpine is an alkaloid compound derived from Evodia rutaecarpa (Chinese herb) traditionally used in herbal medicine. Emerging research suggests potential thermogenic and metabolic effects, though human clinical evidence remains limited.
Primary uses
- sleep support
- thermogenesis
- circulation
How it works
- TRPV1 channel activation (potential thermogenic effect)
- Possible sympathomimetic activity
- Traditional use for circulation and warming
Dosage
- Typical range
- 50-200 mg daily (varies by formulation)
- Timing
- evening for sleep support
- With food
- can be taken with or without food
- Duration
- typical use in sleep blends is short-term (acute sleep support)
- Special populations
- Insufficient data for pregnancy/nursing; use with caution in cardiovascular conditions
Forms
- powder· 70/100
Safety
Common side effects
- hyperactivity (at higher doses)
- insomnia (paradoxical)
- gastrointestinal upset
Contraindications
- cardiovascular disease (sympathomimetic potential)
- uncontrolled hypertension
- palpitations
Evidence notes
Very limited human clinical data. Most evidence is in vitro or animal-based. Insufficient RCTs for sleep efficacy in humans. Marketed as thermogenic/circulation support but sleep-specific evidence is weak.
Grade D: Primarily pre-clinical or anecdotal; human efficacy not established.
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