Herbal Extract
Centella asiatica Extract (Gotu Kola)
Also known as: Gotu Kola Extract, Indian Pennywort Extract, Centella Extract, Cica Extract
Centella asiatica is a traditional Asian herb standardized for triterpenes and madecassosides, studied for cognitive support, skin health, and venous function. Evidence supports modest benefits for microcirculation and wound healing, with emerging data on cognitive effects.
Primary uses
- Cognitive function and mental clarity
- Venous insufficiency and microcirculation
- Skin health and collagen synthesis
- Wound healing and tissue repair
- Anxiety and stress support
How it works
- Triterpenes and madecassosides enhance collagen synthesis and angiogenesis
- Antioxidant and anti-inflammatory effects on vascular endothelium
- May improve cerebral blood flow and neuroprotection
- Modulation of connective tissue remodeling via fibroblast activation
Dosage
- Typical range
- 300-1500 mg daily (standardized extract)
- Timing
- With meals for optimal absorption
- With food
- Recommended to enhance absorption and reduce GI upset
- Duration
- Benefits typically observed after 4-8 weeks of consistent use
- Special populations
- Generally safe in pregnancy at standard doses; consult healthcare provider. Caution in sedative users or those with upcoming surgery.
Forms
- Capsule· 70/100
- Powder· 70/100
- Liquid Extract· 70/100
- Standardized Extract· 70/100
Safety
Common side effects
- Mild gastrointestinal upset
- Dizziness or headache (rare)
- Nausea at high doses
- Allergic contact dermatitis (topical use)
Contraindications
- Pregnancy (theoretical concern; evidence mixed)
- Concurrent sedative medications (additive CNS effects possible)
- Scheduled surgery (may affect bleeding/clotting; discontinue 2 weeks prior)
- Known allergy to Apiaceae family plants
Evidence notes
Solid clinical evidence for venous insufficiency and wound healing; moderate evidence for cognitive effects. Multiple RCTs support microcirculation benefits, though cognitive outcomes are less consistently demonstrated. Well-researched traditional herb with established safety profile.
Grade B: Some human trials support key claims; further confirmation needed.
Related in Herbal Extract
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerMedical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.