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Adaptogen

Rhodiola rosea Extract (root) - Rosavins + Salidroside

Also known as: Rhodiola rosea, Golden Root, SHR-5, Rhodeola

B
Evidence

Rhodiola rosea is a well-researched Arctic adaptogenic herb standardized to contain both rosavins and salidroside, the two primary active compound classes supporting stress resilience and mental performance. This dual-marker formulation provides comprehensive active constituent coverage.

Primary uses

  • Stress and anxiety reduction
  • Mental fatigue and cognitive function
  • Physical endurance and recovery
  • Mood support
  • Work-related stress resilience

How it works

  • Modulation of HPA axis and cortisol regulation
  • Monoamine neurotransmitter enhancement (serotonin, dopamine, norepinephrine)
  • Cellular energy production and mitochondrial function
  • Antioxidant and neuroprotective effects
  • Anti-inflammatory signaling

Dosage

Typical range
300-600 mg daily (standardized extract)
Timing
Morning to early afternoon; avoid evening to prevent insomnia
With food
May be taken with or without food; consistent timing enhances benefits
Duration
Effects often observed within 1-2 weeks; safe for long-term use (6+ months). Adaptogenic effects compound over time.
Special populations
Generally well-tolerated; caution in pregnancy/lactation and bipolar disorder

Forms

  • Extract (dual-standardized)· 70/100

Safety

Common side effects

  • Mild insomnia (if taken too late)
  • Mild headache (rare, usually early use)
  • Mild dizziness (uncommon)

Contraindications

  • Bipolar disorder (may increase mood cycling)
  • Pregnancy and lactation (insufficient safety data)
  • Acute mania or psychosis

Evidence notes

Solid RCT evidence from multiple studies demonstrating efficacy for stress, fatigue, and cognitive function. Standardized to both rosavins (3%) and salidroside (1%), the two major bioactive classes identified in clinical research.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.