Adaptogen
Reishi (Ganoderma lucidum s.l.)
Also known as: Ganoderma lucidum, lingzhi, reishi extract, reishi mycelium
Reishi is a polypore mushroom used for centuries in Traditional Chinese Medicine as an adaptogenic tonic for stress, sleep, and immune support. Moderate clinical evidence supports anxiolytic and sleep-promoting effects.
Primary uses
- stress reduction
- sleep support
- immune support
- relaxation
How it works
- polysaccharide and triterpene-mediated adaptogenic effects
- GABAergic pathway modulation
- immunomodulation
- stress hormone regulation
Dosage
- Typical range
- 1,000–2,500 mg daily (dried mycelium biomass); extract forms often 300–900 mg
- Timing
- evening for sleep support; morning/throughout day for general adaptogenic effects
- With food
- may be taken with or without food
- Duration
- Safe for long-term chronic use; benefits may emerge over 4–12 weeks
- Special populations
- Pregnant/nursing women should consult healthcare provider; immunosuppressed patients should check with provider
Forms
- mycelium biomass on rice· 70/100
- extract· 70/100
- powder· 70/100
- standardized extract· 70/100
Safety
Common side effects
- rare: mild GI upset, dizziness
- occasional dry mouth
Contraindications
- immunosuppressant therapy (theoretical concern)
- bleeding disorders (high-dose triterpenes theoretically anticoagulant)
Evidence notes
Multiple human trials show benefits for sleep, anxiety, and immune markers. Evidence is moderate quality; some studies are small or lack rigorous controls, but consistent benefit signals exist.
Grade B: Some human trials support key claims; further confirmation needed.
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