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Hormone

Melatonin (GERD Support)

B
Evidence

Sleep hormone that also supports lower esophageal sphincter function and may help GERD symptoms.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • GERD support
  • LES function
  • Sleep
  • GI motility

How it works

  • Strengthens lower esophageal sphincter
  • Reduces gastric acid secretion
  • Antioxidant in esophagus
  • Supports GI motility

Dosage

Typical range
3-6mg at bedtime for GERD (higher than sleep doses)
Timing
Bedtime
With food
Either way
Duration
Ongoing as needed
Special populations
GERD, especially nighttime reflux

Forms

  • Capsules/tablets
  • Sublingual

Safety

Common side effects

  • Morning grogginess
  • Vivid dreams
  • Headache

Contraindications

  • Autoimmune diseases (theoretical)
  • Depression (may worsen in some)

Products containing Melatonin (GERD Support)

Top-scoring supplements in our catalog that list Melatonin (GERD Support) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne
Melaton-3™
92
Thorne
Melaton-5™
92
Seed
• PM-02™ Sleep + Restore Supplement
86
See all products →

Evidence notes

Emerging evidence for GERD at higher doses

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.