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Hormone

Progesterone Cream (Bio-identical)

Also known as: Bio-identical progesterone, Micronized progesterone cream, Progest

B
Evidence

Actual progesterone in cream form, requires practitioner guidance for hormone therapy.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Progesterone supplementation
  • Luteal phase support
  • Menopause

How it works

  • Delivers actual progesterone
  • Transdermal absorption
  • Supports luteal phase
  • Menopause hormone therapy

Dosage

Typical range
Varies - OTC 20-40mg/application, Rx as prescribed
Timing
Often luteal phase days 14-28
With food
N/A (topical)
Duration
Per practitioner guidance
Special populations
Women with low progesterone, luteal phase defect, menopause

Forms

  • Cream
  • OTC low-dose
  • Prescription

Safety

Common side effects

  • Skin irritation
  • Drowsiness
  • Mood changes

Contraindications

  • Breast cancer history
  • Liver disease
  • Undiagnosed bleeding

Evidence notes

Effective for progesterone delivery when properly prescribed

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.