Hormone

Progesterone Cream (Bio-identical)

Also known as: Bio-identical progesterone, Micronized progesterone cream, Progest

Evidence

Actual progesterone in cream form, requires practitioner guidance for hormone therapy.

Primary uses

Progesterone supplementation
Luteal phase support
Menopause

How it works

Delivers actual progesterone
Transdermal absorption
Supports luteal phase
Menopause hormone therapy

Dosage

Typical range: Varies - OTC 20-40mg/application, Rx as prescribed
Timing: Often luteal phase days 14-28
With food: N/A (topical)
Duration: Per practitioner guidance
Special populations: Women with low progesterone, luteal phase defect, menopause

Forms

Cream
OTC low-dose
Prescription

Safety

Common side effects

Skin irritation
Drowsiness
Mood changes

Contraindications

Breast cancer history
Liver disease
Undiagnosed bleeding

Evidence notes

Effective for progesterone delivery when properly prescribed

Grade B: Some human trials support key claims; further confirmation needed.

Related in Hormone

Melatonin (GERD Support)B

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.