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Essential Fatty Acid

Evening Primrose Oil (PMS)

Also known as: EPO, GLA, Oenothera biennis oil

C
Evidence

GLA-rich oil traditionally used for PMS breast tenderness and hormonal symptoms.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • PMS breast tenderness
  • Hormonal skin
  • PMS symptoms

How it works

  • Provides GLA
  • May reduce breast tenderness
  • Anti-inflammatory prostaglandins
  • Traditional PMS support

Dosage

Typical range
500-3000mg daily
Timing
With meals, divided
With food
Yes
Duration
2-3 cycles for effect
Special populations
PMS, especially breast tenderness

Forms

  • Softgels
  • Liquid oil

Safety

Common side effects

  • GI upset
  • Headache

Contraindications

  • Seizure disorders
  • Before surgery

Evidence notes

Mixed evidence, traditionally used for PMS breast symptoms

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.