Mineral
Chloride
Also known as: Chloride ion, Cl-
Essential electrolyte mineral that works with sodium and potassium to maintain fluid balance, nerve transmission, and stomach acid production.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Fluid balance
- Electrolyte replenishment
- Digestive support
- Nerve function
How it works
- Major extracellular anion
- Required for stomach acid (HCl) production
- Works with sodium to maintain osmotic pressure
- Essential for carbon dioxide transport in blood
Dosage
- Typical range
- 2300 mg daily (adequate intake)
- Timing
- Throughout day with fluids
- With food
- With or without
- Duration
- Daily requirement
- Special populations
- Athletes may need more during exercise
Forms
- Sodium chloride
- Potassium chloride
- Magnesium chloride
Safety
Common side effects
- Well tolerated at normal doses
Contraindications
- Severe kidney disease
- Hyperchloremia
Products containing Chloride
Top-scoring supplements in our catalog that list Chloride on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Essential mineral with well-established physiological roles
Grade A: Multiple well-designed human trials support the main claims.
Cited research for Chloride
Clinical studies referenced across Formulate guides that mention chloride. Each links to the full study page with PubMed source + the guides that cite it.
Related in Mineral
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does Chloride fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.