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BioPerine® (Black Pepper Extract)
Also known as: Piper nigrum extract, black pepper extract, piperine, BioPerine
BioPerine® is a standardized black pepper fruit extract containing piperine, primarily used as a bioenhancer to increase the absorption and bioavailability of other nutrients and compounds. Clinical evidence supports its ability to enhance nutrient absorption, though its standalone health benefits are limited.
Primary uses
- Nutrient bioavailability enhancement
- Bioavailability booster for other supplements
- Potential anti-inflammatory support
How it works
- Inhibition of intestinal glucuronidation and sulfation (Phase II metabolism)
- Increased intestinal blood flow
- Enhanced gastrointestinal absorption of co-administered compounds
Dosage
- Typical range
- 5-20 mg daily (95% piperine standardization)
- Timing
- With meals, ideally with other supplements/nutrients
- With food
- Recommended with food to enhance absorption of co-ingredients
- Duration
- Safe for long-term use; typically used continuously as part of supplement formulations
- Special populations
- Generally recognized as safe; pregnant/nursing women should consult healthcare provider
Forms
- Capsule· 70/100
- Powder· 70/100
- Tablet· 70/100
Safety
Common side effects
- Generally well-tolerated at recommended doses
- Rare: mild gastrointestinal upset at very high doses
Contraindications
- Individuals with gastrointestinal ulcers (high-dose use)
- Those taking medications requiring careful dose timing (may enhance absorption)
Products containing BioPerine® (Black Pepper Extract)
Top-scoring supplements in our catalog that list BioPerine® (Black Pepper Extract) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Good evidence for bioenhancement function in human studies; multiple RCTs demonstrate increased absorption of curcumin, beta-carotene, and other nutrients. Limited evidence for standalone health benefits; most research focuses on its role as an adjuvant.
Grade B: Some human trials support key claims; further confirmation needed.
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