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BioPerine® (Black Pepper Extract)
Also known as: Piper nigrum extract, black pepper extract, piperine, BioPerine
BioPerine® is a standardized black pepper fruit extract containing piperine, primarily used as a bioenhancer to increase the absorption and bioavailability of other nutrients and compounds. Clinical evidence supports its ability to enhance nutrient absorption, though its standalone health benefits are limited.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Nutrient bioavailability enhancement
- Bioavailability booster for other supplements
- Potential anti-inflammatory support
How it works
- Inhibition of intestinal glucuronidation and sulfation (Phase II metabolism)
- Increased intestinal blood flow
- Enhanced gastrointestinal absorption of co-administered compounds
Dosage
- Typical range
- 5-20 mg daily (95% piperine standardization)
- Timing
- With meals, ideally with other supplements/nutrients
- With food
- Recommended with food to enhance absorption of co-ingredients
- Duration
- Safe for long-term use; typically used continuously as part of supplement formulations
- Special populations
- Generally recognized as safe; pregnant/nursing women should consult healthcare provider
Forms
- Capsule· 70/100
- Powder· 70/100
- Tablet· 70/100
Safety
Common side effects
- Generally well-tolerated at recommended doses
- Rare: mild gastrointestinal upset at very high doses
Contraindications
- Individuals with gastrointestinal ulcers (high-dose use)
- Those taking medications requiring careful dose timing (may enhance absorption)
Products containing BioPerine® (Black Pepper Extract)
Top-scoring supplements in our catalog that list BioPerine® (Black Pepper Extract) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Good evidence for bioenhancement function in human studies; multiple RCTs demonstrate increased absorption of curcumin, beta-carotene, and other nutrients. Limited evidence for standalone health benefits; most research focuses on its role as an adjuvant.
Grade B: Some human trials support key claims; further confirmation needed.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.