SAMe
Scored by the Formulate Research Team · Last reviewed July 2026
Score Breakdown
Three factors carry this score; three more are checked separately and can only take points away. Hover or tap to see what drove each one.
Ingredients per Serving
| Ingredient | Amount |
|---|---|
| SAMe | 200 mg |
Certifications & Testing
Other Ingredients
Microcrystalline Cellulose, Stearic Acid, Glycerol, Sodium Alginate, Colloidal Silica Anhydrous, Arginine, Magnesium Stearate, Magnesium Stearate, Colloidal Silica Anhydrous
Recommended Use
Suggested Usage (for adults only): Take on an empty stomach during the day. For mood balance: 1-4 tablets 2 times per day or as directed by a health professional. For joint support: 1-3 tablets 2 times per day or as directed by a health professional. Do not exceed a total of 8 tablets per day. For best results, take SAMe for a minimum of 2 weeks, at which time effects should be observed.
Warnings
Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding or trying to conceive, or if you are taking medication, have a medical condition or anticipate a surgery. Individuals with bipolar disorder or depression, anxiety disorders, or taking antidepressant medication should consult their health professional prior to use. Keep out of the reach
Frequently Asked Questions
What is Natural Factors SAMe's Formulate score?
Natural Factors SAMe scores 72 out of 100 (grade B) on Formulate's ingredient-level rubric: clinical evidence, dose accuracy and bioavailability carry the score, while manufacturing, transparency and safety are checked separately and can only deduct.
Is Natural Factors SAMe worth it?
Natural Factors SAMe scores 72/100 (grade B). That's an above-average result — most of its doses and ingredient forms are well-chosen, with only minor gaps in dosing, transparency, or testing. Formulate grades every product with the same automated rubric, so the score reflects the formula — not marketing or sponsorships.
What's in Natural Factors SAMe?
Each serving contains SAMe (200 mg). Serving size: 1 Tablet(s). 60 servings per container.
How do I take same?
Suggested Usage (for adults only): Take on an empty stomach during the day. For mood balance: 1-4 tablets 2 times per day or as directed by a health professional. For joint support: 1-3 tablets 2 times per day or as directed by a health professional. Do not exceed a total of 8 tablets per day. For best results, take SAMe for a minimum of 2 weeks, at which time effects should be observed.
Who makes SAMe?
SAMe is made by Natural Factors. See Formulate's full grade and product lineup for Natural Factors on its brand page.
Is Natural Factors SAMe third-party tested?
Natural Factors lists the following certifications and testing for this product: Vegan, Vegetarian, Gluten-Free, Dairy-Free.
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Disclosure. Formulate may earn a commission from purchases made through links on this page. Commissions never influence scores — every product is graded by the same automated rubric. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.