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Jarrow Formulas SAMe - 400mg

SAMe - 400mg

80A-
Grade A- · tablet · 60 servings · $75.99
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Scored by the Formulate Research Team · Last reviewed July 2026

Score Breakdown

Three factors carry this score; three more are checked separately and can only take points away. Hover or tap to see what drove each one.

Evidence Qualityweight 40%
85/ 100
Dose Adequacyweight 35%
95/ 100
Form/Bioavailabilityweight 25%
75/ 100
Transparencyweight 0%
70/ 100
Safety/Redundancyweight 0%
100/ 100
Manufacturing Qualityweight 0%
84/ 100

Ingredients per Serving

IngredientAmount
S-Adenosyl Methionine400 mg

Certifications & Testing

Gluten-FreeNon-GMOVeganVegetarianDairy-Free

Other Ingredients

Microcrystalline Cellulose, Hypromellose Acetate Succinate, Stearic Acid, Triethyl Citrate, Riboflavin, Glyceryl Behenate, Magnesium Stearate, Silicon Dioxide, Mannitol, Sodium Starch Glycolate

Recommended Use

On an empty stomach

Suggested Use: Adults take 1 tablet once a day on an empty stomach or as directed by your qualified healthcare professional.

Warnings

Warning: Do not use if pregnant or nursing. Individuals with Parkinson’s disease, bi-polar disorder, or manic depression should not use this product. May cause gastrointestinal upset in some persons. Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and MAO inhibitors)

Frequently Asked Questions

What is Jarrow Formulas SAMe - 400mg's Formulate score?

Jarrow Formulas SAMe - 400mg scores 80 out of 100 (grade A-) on Formulate's ingredient-level rubric: clinical evidence, dose accuracy and bioavailability carry the score, while manufacturing, transparency and safety are checked separately and can only deduct.

Is Jarrow Formulas SAMe - 400mg worth it?

Jarrow Formulas SAMe - 400mg scores 80/100 (grade A-). That puts it in Formulate's top tier: its ingredient doses, forms, and label transparency hold up against the clinical evidence, and it carries credible third-party testing. Formulate grades every product with the same automated rubric, so the score reflects the formula — not marketing or sponsorships.

What's in Jarrow Formulas SAMe - 400mg?

Each serving contains S-Adenosyl Methionine (400 mg). Serving size: 1 Tablet(s). 60 servings per container.

How do I take same - 400mg?

Suggested Use: Adults take 1 tablet once a day on an empty stomach or as directed by your qualified healthcare professional.

Who makes SAMe - 400mg?

SAMe - 400mg is made by Jarrow Formulas. See Formulate's full grade and product lineup for Jarrow Formulas on its brand page.

Is Jarrow Formulas SAMe - 400mg third-party tested?

Jarrow Formulas lists the following certifications and testing for this product: Gluten-Free, Non-GMO, Vegan, Vegetarian, Dairy-Free.

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Disclosure. Formulate may earn a commission from purchases made through links on this page. Commissions never influence scores — every product is graded by the same automated rubric. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.