Primary Research · 2006
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis (GAIT trial)
Clegg DO, Reda DJ, Harris CL, et al. · New England Journal of Medicine, 2006
Key finding
24-week NIH-funded RCT (n=1,583) found glucosamine + chondroitin did not beat placebo for overall knee OA pain — but did benefit the moderate-to-severe pain subgroup, framing glucosamine as condition-specific rather than universally effective.
Read the paper
Open on PubMedhttps://pubmed.ncbi.nlm.nih.gov/16495392/
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