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kava and benzodiazepines

Kava + Benzos: Excessive sedation risk

What's happening

Both kava and benzodiazepines enhance GABA activity. Combined, can cause profound sedation, respiratory depression, coma. One case report of patient becoming comatose.

Recommendation

Do NOT combine kava with benzodiazepines or other sedatives.

Timing

Avoid combination entirely

Sources

  • — Annals of Internal Medicine
  • — PMID: 9382666

Frequently Asked Questions

Can I take kava and benzodiazepines together?

Kava + Benzos: Excessive sedation risk. Do NOT combine kava with benzodiazepines or other sedatives.

How should I time kava and benzodiazepines?

Avoid combination entirely

Is this interaction dangerous?

This interaction is rated “Danger” by Formulate. Both kava and benzodiazepines enhance GABA activity. Combined, can cause profound sedation, respiratory depression, coma. One case report of patient becoming comatose.

Learn more about each substance

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.

Last medically reviewed: