Grapefruit dramatically increases drug levels
Grapefruit inhibits CYP3A4 enzyme in gut, preventing first-pass metabolism. Can increase blood levels of felodipine by 300%, amlodipine by 50%. Risk of severe hypotension, edema, and arrhythmias. Effect lasts 24+ hours.
Avoid grapefruit and grapefruit juice with CCBs. One glass can cause interaction.
Avoid entirely - timing separation doesn't help
Grapefruit dramatically increases drug levels. Avoid grapefruit and grapefruit juice with CCBs. One glass can cause interaction.
Avoid entirely - timing separation doesn't help
This interaction is rated “Warning” by Formulate. Grapefruit inhibits CYP3A4 enzyme in gut, preventing first-pass metabolism. Can increase blood levels of felodipine by 300%, amlodipine by 50%. Risk of severe hypotension, edema, and arrhythmias. Effect lasts 24+ hours.
The free checker lets you add any combination of supplements and medications at once. Formulate's desktop app goes further — every stack change surfaces interaction alerts automatically.
Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.