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ace inhibitors and potassium

Risk of dangerous hyperkalemia

What's happening

ACE inhibitors (lisinopril, enalapril, ramipril) reduce potassium excretion. Adding potassium supplements can cause life-threatening hyperkalemia (high potassium), leading to fatal cardiac arrhythmias. Symptoms include muscle weakness, paralysis, heart palpitations.

Recommendation

Do NOT supplement potassium while on ACE inhibitors without doctor approval and monitoring.

Timing

Monitor potassium levels regularly if combining

Sources

  • — New England Journal of Medicine
  • — FDA ACE Inhibitor Labels
  • — PMID: 16007097

Frequently Asked Questions

Can I take ace inhibitors and potassium together?

Risk of dangerous hyperkalemia. Do NOT supplement potassium while on ACE inhibitors without doctor approval and monitoring.

How should I time ace inhibitors and potassium?

Monitor potassium levels regularly if combining

Is this interaction dangerous?

This interaction is rated “Danger” by Formulate. ACE inhibitors (lisinopril, enalapril, ramipril) reduce potassium excretion. Adding potassium supplements can cause life-threatening hyperkalemia (high potassium), leading to fatal cardiac arrhythmias. Symptoms include muscle weakness, paralysis, heart palpitations.

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Related reading

Other interactions to know

More interactions involving ace inhibitors or potassium

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.

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