Herbal Extract
Tetrahydromagnolol
Also known as: Magnolia officinalis extract, Magnolol hydrogenation product, Tetrahydro-magnolol, Magnolia bark extract
A semi-synthetic derivative or bioactive from Magnolia officinalis bark that exhibits anxiolytic and neuroprotective properties. Often studied as part of magnolia bark extract formulations for relaxation and emotional support.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Anxiety and stress relief
- Relaxation and mood support
- Sleep quality improvement
- Neuroprotection
How it works
- GABAergic modulation (GABA receptor agonism)
- Anxiolytic activity via limbic system
- Reduction of cortisol and stress markers
- Antioxidant and anti-inflammatory effects
- Potential monoamine modulation
Dosage
- Typical range
- 100–300 mg daily (as formulated; exact dosage varies by product)
- Timing
- Evening or as needed for relaxation; may take 2–4 weeks for adaptation
- With food
- Can be taken with or without food
- Duration
- Regular use typically recommended; no established upper limit, but long-term safety data is limited
- Special populations
- Pregnancy/nursing: avoid; pediatrics: insufficient data
Forms
- Proprietary extract· 70/100
- Standardized bark derivative· 70/100
- Capsule· 70/100
- Often in multi-ingredient formulas· 70/100
Safety
Common side effects
- Generally well tolerated at recommended doses
- Drowsiness (desired effect in some contexts)
- Rare headache or GI upset
Contraindications
- Pregnancy and lactation
- Driving or operating machinery if sedation occurs
- Concurrent use with strong sedatives without medical guidance
Products containing Tetrahydromagnolol
Top-scoring supplements in our catalog that list Tetrahydromagnolol on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Limited clinical trials specifically on tetrahydromagnolol; most evidence derives from magnolia bark extract and honokiol/magnolol studies. Animal and in vitro data support mechanism, but robust human RCTs are lacking for this isolated derivative.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Herbal Extract
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.