Herbal Extract
Tetrahydromagnolol
Also known as: Magnolia officinalis extract, Magnolol hydrogenation product, Tetrahydro-magnolol, Magnolia bark extract
A semi-synthetic derivative or bioactive from Magnolia officinalis bark that exhibits anxiolytic and neuroprotective properties. Often studied as part of magnolia bark extract formulations for relaxation and emotional support.
Primary uses
- Anxiety and stress relief
- Relaxation and mood support
- Sleep quality improvement
- Neuroprotection
How it works
- GABAergic modulation (GABA receptor agonism)
- Anxiolytic activity via limbic system
- Reduction of cortisol and stress markers
- Antioxidant and anti-inflammatory effects
- Potential monoamine modulation
Dosage
- Typical range
- 100–300 mg daily (as formulated; exact dosage varies by product)
- Timing
- Evening or as needed for relaxation; may take 2–4 weeks for adaptation
- With food
- Can be taken with or without food
- Duration
- Regular use typically recommended; no established upper limit, but long-term safety data is limited
- Special populations
- Pregnancy/nursing: avoid; pediatrics: insufficient data
Forms
- Proprietary extract· 70/100
- Standardized bark derivative· 70/100
- Capsule· 70/100
- Often in multi-ingredient formulas· 70/100
Safety
Common side effects
- Generally well tolerated at recommended doses
- Drowsiness (desired effect in some contexts)
- Rare headache or GI upset
Contraindications
- Pregnancy and lactation
- Driving or operating machinery if sedation occurs
- Concurrent use with strong sedatives without medical guidance
Products containing Tetrahydromagnolol
Top-scoring supplements in our catalog that list Tetrahydromagnolol on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Limited clinical trials specifically on tetrahydromagnolol; most evidence derives from magnolia bark extract and honokiol/magnolol studies. Animal and in vitro data support mechanism, but robust human RCTs are lacking for this isolated derivative.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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