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Herbal Extract

Split Gill Polypore

Also known as: Schizophyllum commune, split gills, oyster mushroom relative

C
Evidence

A common wood-colonizing fungus with a distinctive split-gill morphology, traditionally used in Asian cuisines and folk medicine for immune modulation. Clinical evidence in humans is minimal and mostly theoretical.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Immune support
  • General wellness
  • Antioxidant support

How it works

  • Purported beta-glucan and polysaccharide content
  • Proposed immunomodulating compounds in laboratory studies
  • Traditional use suggests adaptogenic properties

Dosage

Typical range
500-1500 mg daily (as part of mushroom blends)
Timing
With meals preferred
With food
Recommended to enhance bioavailability
Duration
Long-term safety profile not well characterized
Special populations
Avoid in immunocompromised individuals without medical supervision; pregnancy/lactation data unavailable

Forms

  • Mycelium on rice biomass· 70/100
  • Fruiting body extracts· 70/100

Safety

Contraindications

  • Possible allergic reaction in mold-sensitive individuals
  • Theoretical concern for immunocompromised populations

Evidence notes

Laboratory and animal studies show potential bioactive compounds, but human clinical trials are absent or extremely limited. Mycelial biomass on rice substrate form lacks specific human efficacy data.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.