Herbal Extract
Split Gill Polypore
Also known as: Schizophyllum commune, split gills, oyster mushroom relative
A common wood-colonizing fungus with a distinctive split-gill morphology, traditionally used in Asian cuisines and folk medicine for immune modulation. Clinical evidence in humans is minimal and mostly theoretical.
Primary uses
- Immune support
- General wellness
- Antioxidant support
How it works
- Purported beta-glucan and polysaccharide content
- Proposed immunomodulating compounds in laboratory studies
- Traditional use suggests adaptogenic properties
Dosage
- Typical range
- 500-1500 mg daily (as part of mushroom blends)
- Timing
- With meals preferred
- With food
- Recommended to enhance bioavailability
- Duration
- Long-term safety profile not well characterized
- Special populations
- Avoid in immunocompromised individuals without medical supervision; pregnancy/lactation data unavailable
Forms
- Mycelium on rice biomass· 70/100
- Fruiting body extracts· 70/100
Safety
Contraindications
- Possible allergic reaction in mold-sensitive individuals
- Theoretical concern for immunocompromised populations
Evidence notes
Laboratory and animal studies show potential bioactive compounds, but human clinical trials are absent or extremely limited. Mycelial biomass on rice substrate form lacks specific human efficacy data.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Herbal Extract
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerMedical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.