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Fatty Acid

Safflower Seed Oil Concentrate

Also known as: CLA safflower oil, conjugated linoleic acid oil, safflower oil extract, high-linoleic safflower oil

C
Evidence

Safflower seed oil concentrate is used as a carrier and source of conjugated linoleic acid (CLA), a polyunsaturated fatty acid with preliminary evidence for body composition support. The concentrate typically provides 750-1250 mg of CLA per serving in supplement formulations.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Body composition support
  • CLA delivery
  • Metabolic health

How it works

  • CLA may modulate fat metabolism and promote fat oxidation
  • Potential effects on adipose tissue regulation
  • Serves as carrier oil for CLA bioavailability

Dosage

Typical range
750-1500 mg CLA daily (from safflower oil concentrate)
Timing
With meals to enhance absorption
With food
Recommended with food containing fat
Duration
Consistent use for 12+ weeks typically needed to observe potential effects
Special populations
Pregnancy/lactation: limited safety data; consult healthcare provider

Forms

  • Softgel capsules· 70/100
  • Liquid oil· 70/100
  • Triglyceride form· 70/100

Safety

Common side effects

  • Gastrointestinal upset
  • Loose stools
  • Bloating
  • Nausea

Contraindications

  • Safflower allergy/sensitivity
  • Bleeding disorders (theoretical risk from increased polyunsaturated fat intake)

Evidence notes

CLA itself has moderate evidence from mixed clinical trials showing modest body composition benefits (typically 0.5-1.5 kg fat loss over 12 weeks). However, safflower oil as a delivery vehicle lacks robust direct clinical data; efficacy depends on CLA content and quality standardization.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.